Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39 64 Years [Published online Keio J Med, 65, 33-38, by J-STAGE]

[Published online The Keio Journal of Medicine Vol.65, 33-38, by J-STAGE]
<Title:> Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39 64 Years
<Author(s):> Takeshi Miyamoto, Eri Katsuyama, Hiroya Kanagawa, Atsuhiro Fujie, Hiroya Miyamoto, Shigeyuki Yoshida, Tomoaki Mori, Kana Miyamoto, Yuiko Sato, Tami Kobayashi, Masaya Nakamura, Morio Matsumoto, Yuji Nishiwaki, Hiroshi Hirose, Takeshi Kanda, Ikuo Saito, Yoshiaki Toyama
<Corresponding author E-Mill:> miyamoto(at)z5.keio.jp
<Abstract:> Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderly osteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39 64 years who were not receiving medication for osteoporosis or other bone diseases. Serum 25(OH)D levels were positively correlated with age (P = 0.019), whereas intact PTH levels were inversely correlated with 25(OH)D levels (P < 0.001). Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Our data show that serum 25(OH)D insufficiency could be a more serious concern in the younger population than had been previously anticipated. Because serum 25(OH)D insufficiency is reportedly a risk factor for hip and spine fracture, the number of fracture patients could increase in the future, suggesting that we may need to correct the serum vitamin D/intact PTH status to prevent future osteoporosis.
<Keywords:> vitamin D, parathyroid hormone, osteoporosis, young adult women
<URL:> https://www.jstage.jst.go.jp/article/kjm/65/2/65_2015-0010-OA/_article