Warfarin Therapy and Percutaneous Left Atrial Appendage Closure for a Patient with Atrial Fibrillation and Antithrombin-III Deficiency [Published online Keio J Med, 73, 27-30, by J-STAGE]

[Published online The Keio Journal of Medicine Vol.73, 27-30, by J-STAGE]
<Title:> Warfarin Therapy and Percutaneous Left Atrial Appendage Closure for a Patient with Atrial Fibrillation and Antithrombin-III Deficiency
<Author(s):> Sho Shimohama, Masahiro Katsumata, Shumpei Azami, Satoshi Kitagawa, Hikaru Tsuruta, Taku Inohara, Jin Nakahara, Yoshikane Izawa
<Abstract:> Some patients develop ischemic stroke despite taking direct oral anticoagulants because of the presence of other risk factors such as coagulopathies. A 65-year-old male patient with non-valvular atrial fibrillation (NVAF) taking rivaroxaban was diagnosed as having embolic stroke and antithrombin-III (AT-III) deficiency. Echocardiography revealed a thrombus in the left atrial appendage (LAA). He was prescribed warfarin, and after resolution of the thrombus, we successfully performed percutaneous LAA closure (LAAC), with no subsequent recurrence or device-related thrombosis. Warfarin and LAAC may be feasible for NVAF patients with AT-III deficiency.
<Keywords:> left atrial appendage thrombus, atrial fibrillation, antithrombin-III deficiency, anticoagulants, ischemic stroke
<URL:> https://www.jstage.jst.go.jp/article/kjm/73/3/73_2023-0017-CR/_html

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